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RSPO1 antibody

RSPO1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 7A6 unconjugated
Catalog No. ABIN969375
  • Target See all RSPO1 Antibodies
    RSPO1 (R-Spondin 1 (RSPO1))
    Reactivity
    • 43
    • 39
    • 34
    • 15
    • 15
    • 15
    • 15
    • 15
    Human
    Host
    • 47
    • 5
    • 1
    Mouse
    Clonality
    • 48
    • 5
    Monoclonal
    Conjugate
    • 22
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This RSPO1 antibody is un-conjugated
    Application
    • 36
    • 15
    • 13
    • 11
    • 11
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of R-spondin1 expressed in E. coli.
    Clone
    7A6
    Isotype
    IgG1
    Top Product
    Discover our top product RSPO1 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

    Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

  • Target
    RSPO1 (R-Spondin 1 (RSPO1))
    Alternative Name
    R-spondin1 (RSPO1 Products)
    Synonyms
    RGD1565558 antibody, CRISTIN3 antibody, RSPO antibody, R-spondin antibody, Rspondin antibody, wu:fj81e05 antibody, zgc:92153 antibody, R-spondin 1 antibody, Rspo1 antibody, RSPO1 antibody, LOC100049655 antibody, rspo1 antibody
    Background

    Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

    Aliases: RSPO1,CRISTIN3,FLJ40906

    Molecular Weight
    28.9 kDa
    Gene ID
    284654
    HGNC
    284654
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