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PSIP1 antibody

PSIP1 Reactivity: Human, Rat, Monkey WB, IHC, ELISA, ICC Host: Mouse Monoclonal 6-00E-04 unconjugated
Catalog No. ABIN969370
  • Target See all PSIP1 Antibodies
    PSIP1 (PC4 and SFRS1 Interacting Protein 1 (PSIP1))
    Reactivity
    • 26
    • 17
    • 11
    • 11
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    Human, Rat, Monkey
    Host
    • 16
    • 13
    Mouse
    Clonality
    • 16
    • 13
    Monoclonal
    Conjugate
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSIP1 antibody is un-conjugated
    Application
    • 19
    • 9
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human PSIP1 expressed in E. coli.
    Clone
    6-00E-04
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Shun, Botbol, Li, Di Nunzio, Daigle, Yan, Lieberman, Lavigne, Engelman: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, (2008) (PubMed).

  • Target
    PSIP1 (PC4 and SFRS1 Interacting Protein 1 (PSIP1))
    Alternative Name
    PSIP1 (PSIP1 Products)
    Synonyms
    PSIP1 antibody, im:7149861 antibody, zgc:109898 antibody, LEDGF antibody, p75 antibody, PSIP2 antibody, DFS70 antibody, PAIP antibody, p52 antibody, AA408851 antibody, AU015605 antibody, Dfs70 antibody, Ledgfa antibody, Ledgfb antibody, Psip2 antibody, Ledgf antibody, SBP75 antibody, LEDGF/p75 antibody, PC4 and SFRS1 interacting protein 1 S homeolog antibody, PC4 and SFRS1 interacting protein 1 antibody, PC4 and SFRS1 interacting protein 1a antibody, LEDGF/p75 transcription factor-like antibody, psip1.S antibody, PSIP1 antibody, psip1a antibody, psip1 antibody, Psip1 antibody
    Background

    Description: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.

    Aliases: p52, p75, PAIP, DFS70, LEDGF, PSIP2, MGC74712, PSIP1

    Molecular Weight
    75 kDa
    Gene ID
    11168
    HGNC
    11168
    Pathways
    Chromatin Binding, Ribonucleoprotein Complex Subunit Organization
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