PGA5 antibody

Catalog No. ABIN969350

Product Details anti-PGA5 Antibody

Target: PGA5 (Pepsinogen 5, Group I (Pepsinogen A) (PGA5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PGA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of human PGA5 expressed in E. coli.

Clone: 2C1

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for PGA5

Target: PGA5 (Pepsinogen 5, Group I (Pepsinogen A) (PGA5))

Alternative Name: PGA5 (PGA5 Products)

Synonyms: PGA3 antibody, PGA4 antibody, 1110035E17Rik antibody, Pepf antibody, pepsinogen 5, group I (pepsinogen A) antibody, pepsinogen 5, group I antibody, PGA5 antibody, Pga5 antibody

Background:

Description: PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity ( pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity, although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Aliases: Pepsinogen 5, Pepsin A

Molecular Weight: 42 kDa

Gene ID: 5222

HGNC: 5222