NAMPT antibody (AA 338-479)

Catalog No. ABIN969344

Product Details anti-NAMPT Antibody

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Binding Specificity: AA 338-479

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NAMPT antibody is un-conjugated

Application: ELISA

Purpose: PBEF1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of PBEF1 (aa338-479) expressed in E. Coli.

Clone: 1D3A12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NAMPT antibody (ABIN969344)

Rongvaux, Shea, Mulks, Gigot, Urbain, Leo, Andris: "Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis." in: European journal of immunology, Vol. 32, Issue 11, pp. 3225-34, (2003) (PubMed).

Target Details for NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Alternative Name: PBEF1 (NAMPT Products)

Background:

Description: PBEF1: nicotinamide phosphoribosyltransferase. This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Aliases: VF, PBEF, PBEF1, VISFATIN, NAMPT

Gene ID: 10135

HGNC: 10135

UniProt: P43490