NCOA3 antibody (AA 1-200)

Catalog No. ABIN969309

Product Details anti-NCOA3 Antibody

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Binding Specificity: AA 1-200

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NCOA3 antibody is un-conjugated

Application: ELISA

Purpose: NCOA3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of NCOA3 (aa1-200) expressed in E. Coli.

Clone: 2C11B12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NCOA3 antibody (ABIN969309)

Rangel, Torabian, Shaikh, Nosrati, Baehner, Haqq, Leong, Miller, Sagebiel, Kashani-Sabet: "Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanoma." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 24, Issue 28, pp. 4565-9, (2006) (PubMed).

Zheng, Wu, Smith, OMalley: "Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor." in: Molecular and cellular biology, Vol. 25, Issue 18, pp. 8273-84, (2005) (PubMed).

Target Details for NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Alternative Name: NCOA3 (NCOA3 Products)

Background:

Description: NCOA3: nuclear receptor coactivator 3. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Aliases: ACTR, AIB1

Gene ID: 8202

HGNC: 8202

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha