MMP1 antibody

Catalog No. ABIN969287

Product Details anti-MMP1 Antibody

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: MMP1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MMP1 expressed in E. Coli.

Clone: 6A5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MMP1 antibody (ABIN969287)

Genevay, Finckh, Mezin, Tessitore, Guerne: "Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation." in: Arthritis research & therapy, Vol. 11, Issue 6, pp. R169, (2010) (PubMed).

Guan, Shu, Fu, Liu, Xu, Wu: "Prevotella intermedia upregulates MMP-1 and MMP-8 expression in human periodontal ligament cells." in: FEMS microbiology letters, Vol. 299, Issue 2, pp. 214-22, (2009) (PubMed).

Target Details for MMP1

Target: MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))

Alternative Name: MMP1 (MMP1 Products)

Background:

Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Aliases: CLG, CLGN

Molecular Weight: 54kDa

Gene ID: 4312

HGNC: 4312

UniProt: P08253