MDM4-binding Protein antibody

Catalog No. ABIN969282

Product Details anti-MDM4-binding Protein Antibody

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MDM4-binding Protein antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: MDM4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MDM4 expressed in E. Coli.

Clone: 2D10F4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MDM4-binding Protein antibody (ABIN969282)

Pan, Chen: "Modification of MDMX by sumoylation." in: Biochemical and biophysical research communications, Vol. 332, Issue 3, pp. 702-9, (2005) (PubMed).

Wunderlich, Ghosh, Weghorst, Berberich: "MdmX represses E2F1 transactivation." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 4, pp. 472-8, (2004) (PubMed).

Target Details for MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Alternative Name: MDM4 (MDM4 Products)

Synonyms: mdmx antibody, HDMX antibody, MDMX antibody, MRP1 antibody, wu:fa09h09 antibody, wu:fi33d10 antibody, 4933417N07Rik antibody, AA414968 antibody, AL023055 antibody, AU018793 antibody, AU021806 antibody, C85810 antibody, Mdmx antibody, MDM4, p53 regulator S homeolog antibody, MDM4, p53 regulator antibody, transformed mouse 3T3 cell double minute 4 antibody, mdm4.S antibody, MDM4 antibody, Mdm4 antibody, mdm4 antibody

Background:

Description: MDM4, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2.

Aliases: HDMX, MDMX, MRP1, MDM4

Molecular Weight: 55kDa

Gene ID: 4194

HGNC: 4194

UniProt: O15151

Pathways: Cell Division Cycle