Lamin A/C antibody
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- Target See all Lamin A/C (LMNA) Antibodies
- Lamin A/C (LMNA)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Lamin A/C antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Purpose
- LMNA Antibody
- Purification
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of human LMNA expressed in E. Coli.
- Clone
- 4E7
- Isotype
- IgG1
- Top Product
- Discover our top product LMNA Primary Antibody
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- Application Notes
- ELISA: 1/10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement." in: Muscle & nerve, Vol. 41, Issue 1, pp. 85-91, (2009) (PubMed).
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Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement." in: Muscle & nerve, Vol. 41, Issue 1, pp. 85-91, (2009) (PubMed).
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- Target
- Lamin A/C (LMNA)
- Alternative Name
- LMNA (LMNA Products)
- Background
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Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Aliases: FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1
- Molecular Weight
- 74kDa
- Gene ID
- 4000
- HGNC
- 4000
- UniProt
- P02545
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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