Laminin beta 1 antibody (AA 31-270)

Catalog No. ABIN969256

Product Details anti-Laminin beta 1 Antibody

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Binding Specificity: AA 31-270

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Laminin beta 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Purpose: LAMB1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.

Clone: 2D9G5

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Laminin beta 1 antibody (ABIN969256)

Fujita, Khazenzon, Bose, Sekiguchi, Sasaki, Carter, Ljubimov, Black, Ljubimova: "Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases." in: Breast cancer research : BCR, Vol. 7, Issue 4, pp. R411-21, (2005) (PubMed).

Virtanen, Korhonen, Petäjäniemi, Karhunen, Thornell, Sorokin, Konttinen: "Laminin isoforms in fetal and adult human adrenal cortex." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 10, pp. 4960-6, (2003) (PubMed).

Target Details for Laminin beta 1

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Alternative Name: LAMB1 (LAMB1 Products)

Synonyms: CLM antibody, LIS5 antibody, fc20b05 antibody, gup antibody, lamb1 antibody, sb:cb95 antibody, wu:fc20b05 antibody, Lamb1-1 antibody, LAMB1 antibody, C77966 antibody, C80098 antibody, C81607 antibody, D130003D08Rik antibody, Lamb-1 antibody, laminin subunit beta 1 antibody, laminin, beta 1a antibody, laminin B1 antibody, LAMB1 antibody, lamb1a antibody, Lamb1 antibody, lamb1 antibody

Background:

Description: LAMB1: laminin, beta 1. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Aliases: CLM, MGC142015

Gene ID: 3912

HGNC: 3912

UniProt: P07942