KRT15 antibody

Catalog No. ABIN969250

Product Details anti-KRT15 Antibody

Target: KRT15 (Keratin 15 (KRT15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT15 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: KRT15 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of KRT15 expressed in E. Coli.

Clone: 6E7

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KRT15 antibody (ABIN969250)

Radoja, Stojadinovic, Waseem, Tomic-Canic, Milisavljevic, Teebor, Blumenberg: "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3168-79, (2004) (PubMed).

Werner, Munz: "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo." in: Experimental cell research, Vol. 254, Issue 1, pp. 80-90, (2000) (PubMed).

Target Details for KRT15

Target: KRT15 (Keratin 15 (KRT15))

Alternative Name: KRT15 (KRT15 Products)

Synonyms: xlk2 antibody, CK15 antibody, K15 antibody, K1CO antibody, AI528832 antibody, Krt1-15 antibody, Ka15 antibody, wu:fa91c06 antibody, wu:fa95d04 antibody, zgc:55334 antibody, keratin 15, type I L homeolog antibody, keratin 15, type I antibody, keratin 15 antibody, krt15.L antibody, krt15 antibody, KRT15 antibody, Krt15 antibody

Background:

Description: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.

Aliases: K15, CK15, K1CO, KRT1

Molecular Weight: 49kDa

Gene ID: 3866

HGNC: 3866

UniProt: P19012