KLHL1 antibody

Catalog No. ABIN969241

Product Details anti-KLHL1 Antibody

Target: KLHL1 (Kelch-Like 1 (KLHL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLHL1 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: KLHL1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human KLHL1 expressed in E. Coli.

Clone: 3A8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KLHL1 antibody (ABIN969241)

Barrios-Rodiles, Brown, Ozdamar, Bose, Liu, Donovan, Shinjo, Liu, Dembowy, Taylor, Luga, Przulj, Robinson, Suzuki, Hayashizaki, Jurisica, Wrana: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, (2005) (PubMed).

Target Details for KLHL1

Target: KLHL1 (Kelch-Like 1 (KLHL1))

Alternative Name: KLHL1 (KLHL1 Products)

Synonyms: mKIAA1490 antibody, MRP2 antibody, kelch like family member 1 antibody, kelch-like 1 antibody, kelch-like family member 1 antibody, KLHL1 antibody, Klhl1 antibody

Background:

Description: The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.

Aliases: MRP2, FLJ30047, KIAA1490, KLHL1

Molecular Weight: 82kDa

Gene ID: 57626

HGNC: 57626

UniProt: Q9NR64