KARS antibody (AA 90-174)

Catalog No. ABIN969226

Product Details anti-KARS Antibody

Target: KARS (Lysyl-tRNA Synthetase (KARS))

Binding Specificity: AA 90-174

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KARS antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Purpose: KARS Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of KARS(aa90-174) expressed in E. Coli.

Clone: 8G12C1

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-KARS antibody (ABIN969226)

Sampath, Mazumder, Seshadri, Gerber, Chavatte, Kinter, Ting, Dignam, Kim, Driscoll, Fox: "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation." in: Cell, Vol. 119, Issue 2, pp. 195-208, (2004) (PubMed).

Sang Lee, Gyu Park, Park, Seol, Lee, Kim: "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex." in: Biochemical and biophysical research communications, Vol. 291, Issue 1, pp. 158-64, (2002) (PubMed).

Cen, Khorchid, Javanbakht, Gabor, Stello, Shiba, Musier-Forsyth, Kleiman: "Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1." in: Journal of virology, Vol. 75, Issue 11, pp. 5043-8, (2001) (PubMed).

Tolkunova, Park, Xia, King, Davidson: "The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35063-9, (2000) (PubMed).

Target Details for KARS

Target: KARS (Lysyl-tRNA Synthetase (KARS))

Alternative Name: KARS (KARS Products)

Synonyms: CG12141 antibody, Dmel\\CG12141 antibody, KRS antibody, LysRS antibody, cb530 antibody, wu:fa16h02 antibody, zgc:92483 antibody, kars antibody, MGC53345 antibody, kars2 antibody, krs antibody, krs-1 antibody, KARS antibody, Tb06.28P18.190 antibody, CMTRIB antibody, DFNB89 antibody, KARS1 antibody, KARS2 antibody, AA589550 antibody, AL024334 antibody, AL033315 antibody, AL033367 antibody, D8Ertd698e antibody, D8Wsu108e antibody, mKIAA0070 antibody, Lysyl-tRNA synthetase antibody, lysyl-tRNA synthetase antibody, lysyl-tRNA synthetase S homeolog antibody, lysyl-tRNA synthetase L homeolog antibody, LysRS antibody, kars antibody, kars.S antibody, kars.L antibody, Bm1_16500 antibody, lysS antibody, Taci_1118 antibody, Tpau_1737 antibody, Arch_0261 antibody, Trad_2960 antibody, Spirs_3699 antibody, KARS antibody, LOC100280510 antibody, Tb927.6.1510 antibody, Kars antibody

Background:

Description: KARS: lysyl-tRNA synthetase. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Aliases: KRS, KARS2, KIAA0070

Gene ID: 3735

HGNC: 3735

UniProt: Q15046