ISL1 antibody

Catalog No. ABIN969219

Product Details anti-ISL1 Antibody

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ISL1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: ISL1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ISL1 expressed in E. Coli.

Clone: 1H9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ISL1 antibody (ABIN969219)

Elshatory, Gan: "The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 13, pp. 3291-7, (2008) (PubMed).

Target Details for ISL1

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Alternative Name: ISL1 (ISL1 Products)

Synonyms: Xisl-1 antibody, Xislet-1 antibody, islet1 antibody, ISLET-1 antibody, ISLET1 antibody, Isl-1 antibody, islet-1 antibody, isl-1=homeobox antibody, Islet-1 antibody, ISL LIM homeobox 1 S homeolog antibody, ISL LIM homeobox 1 antibody, ISL1 transcription factor, LIM/homeodomain antibody, isl1.S antibody, ISL1 antibody, Isl1 antibody, isl1 antibody

Background:

Description: ISL1 (ISL1 transcription factor, LIM/homeodomain) is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young.

Aliases: Isl-1, ISLET1

Molecular Weight: 39kDa

Gene ID: 3670

HGNC: 3670

UniProt: P61371

Pathways: Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding