IGF2BP3 antibody

Catalog No. ABIN969208

Product Details anti-IGF2BP3 Antibody

Target: IGF2BP3 (Insulin-Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGF2BP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purpose: IGF2BP3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human IGF2BP3 expressed in E. Coli.

Clone: 8F11

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IGF2BP3 antibody (ABIN969208)

Sitnikova, Mendese, Liu, Woda, Lu, Dresser, Mohanty, Rock, Jiang: "IMP3 predicts aggressive superficial urothelial carcinoma of the bladder." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 6, pp. 1701-6, (2008) (PubMed).

Target Details for IGF2BP3

Target: IGF2BP3 (Insulin-Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3))

Alternative Name: IGF2BP3 (IGF2BP3 Products)

Background:

Description: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines .IMP-3 is a marker for carcinomas and high-grade dysplastic lesions of pancreatic ductal epithelium.

Aliases: CT98, IMP3, KOC1, IMP-3, VICKZ3, DKFZp686F1078, IGF2BP3

Molecular Weight: 69kDa

Gene ID: 10643

HGNC: 10643

UniProt: O00425