HSPD1 antibody

Catalog No. ABIN969200

Product Details anti-HSPD1 Antibody

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSPD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Purpose: HSP60 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human HSP60 expressed in E. Coli.

Clone: 3G8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HSPD1 antibody (ABIN969200)

López-Hoyos, Alvarez, Ruiz Soto, Blanco, José Bartolomé, Martínez-Taboada: "Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients." in: Clinical and experimental rheumatology, Vol. 26, Issue 6, pp. 1107-10, (2009) (PubMed).

Glaessgen, Jonmarker, Lindberg, Nilsson, Lewensohn, Ekman, Valdman, Egevad: "Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 116, Issue 10, pp. 888-95, (2009) (PubMed).

Target Details for HSPD1

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Alternative Name: HSP60 (HSPD1 Products)

Background:

Description: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. (provided by RefSeq)

Aliases: HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HSP-60, HuCHA60, HSPD1

Molecular Weight: 61kDa

Gene ID: 3329

HGNC: 3329

UniProt: P10809

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity