HFE antibody

Catalog No. ABIN969192

Product Details anti-HFE Antibody

Target: HFE (Hemochromatosis (HFE))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HFE antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: HFE Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human HFE expressed in E. Coli.

Clone: 3F1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HFE antibody (ABIN969192)

Hosgood, Menashe, He, Chanock, Lan: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).

Valenti, Girelli, Valenti, Castagna, Como, Campostrini, Rametta, Dongiovanni, Messa, Fargion: "HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 4, Issue 8, pp. 1331-7, (2009) (PubMed).

Target Details for HFE

Target: HFE (Hemochromatosis (HFE))

Alternative Name: HFE (HFE Products)

Synonyms: HFE1 antibody, HH antibody, HLA-H antibody, MVCD7 antibody, TFQTL2 antibody, MR2 antibody, hemochromatosis antibody, HFE antibody, Hfe antibody

Background:

Description: The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined. 

Aliases: HH; HFE1; HLA-H; MVCD7; TFQTL2; MGC103790; dJ221C16.10.1

Molecular Weight: 40kDa

Gene ID: 3077

HGNC: 3077

UniProt: Q30201

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process