HDAC3 antibody (AA 224-428)

Catalog No. ABIN969188

Product Details anti-HDAC3 Antibody

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Binding Specificity: AA 224-428

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purpose: HDAC3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human HDAC3 (aa224-428) expressed in E. Coli.

Clone: 7G6C5

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HDAC3 antibody (ABIN969188)

Spurling, Godman, Noonan, Rasmussen, Rosenberg, Giardina: "HDAC3 overexpression and colon cancer cell proliferation and differentiation." in: Molecular carcinogenesis, Vol. 47, Issue 2, pp. 137-47, (2008) (PubMed).

Grégoire, Xiao, Nie, Zhang, Xu, Li, Wong, Seto, Yang: "Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2." in: Molecular and cellular biology, Vol. 27, Issue 4, pp. 1280-95, (2007) (PubMed).

Libý, Kostrouchová, Pohludka, Yilma, Hrabal, Sikora, Brozová, Kostrouchová, Rall, Kostrouch: "Elevated and deregulated expression of HDAC3 in human astrocytic glial tumours." in: Folia biologica, Vol. 52, Issue 1-2, pp. 21-33, (2006) (PubMed).

Target Details for HDAC3

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Alternative Name: HDAC3 (HDAC3 Products)

Synonyms: CG2128 antibody, DHDAC3 antibody, DmHDAC3 antibody, Dmel\\CG2128 antibody, Dromel_CG2128_FBtr0078767_hdac3_mORF antibody, HDAC antibody, HDAC3 antibody, Hdac 3 antibody, dHDAC3 antibody, dmHDA402 antibody, hdac3 antibody, HDm antibody, hd3 antibody, RPD3 antibody, XRpd3 antibody, rpd3-2 antibody, HD3 antibody, RPD3-2 antibody, AW537363 antibody, zgc:55927 antibody, Histone deacetylase 3 antibody, histone deacetylase 3 antibody, histone deacetylase 3 S homeolog antibody, HDAC3 antibody, hdac3 antibody, CNL05260 antibody, Hdac3 antibody, hdac3.S antibody

Background:

Description: HDAC3: histone deacetylase 3, also known as HD3, RPD3, RPD3-2. Entrez Protein NC_000005. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Aliases: HD3, RPD3, RPD3-2

Molecular Weight: 48.8kDa

Gene ID: 8841

HGNC: 8841

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development