FYN antibody

Catalog No. ABIN969159

Product Details anti-FYN Antibody

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FYN antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: FYN Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FYN expressed in E. Coli.

Clone: 2A10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FYN antibody (ABIN969159)

Brignatz, Paronetto, Opi, Cappellari, Audebert, Feuillet, Bismuth, Roche, Arold, Sette, Collette: "Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn." in: Molecular and cellular biology, Vol. 29, Issue 24, pp. 6438-48, (2009) (PubMed).

Lu, Zhu, Cvrljevic, Huang, Sarkaria, Ahkavan, Dang, Dinca, Plaisier, Oderberg, Lee, Chen, Caldwell, Xie, Loo, Seligson, Chakravari, Lee, Weinmann, Cloughesy, Nelson, Bergers, Graeber, Furnari, James, Cavenee, Johns, Mischel: "Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients." in: Cancer research, Vol. 69, Issue 17, pp. 6889-98, (2009) (PubMed).

Kitkumthorn, Yanatatsanajit, Kiatpongsan, Phokaew, Triratanachat, Trivijitsilp, Termrungruanglert, Tresukosol, Niruthisard, Mutirangura: "Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer." in: BMC cancer, Vol. 6, pp. 55, (2006) (PubMed).

Target Details for FYN

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Alternative Name: FYN (FYN Products)

Synonyms: im:6908851 antibody, si:dkey-119m7.5 antibody, zgc:109996 antibody, c-fyn antibody, cfyn-a antibody, SLK antibody, SYN antibody, p59-FYN antibody, PKC antibody, fyn antibody, zgc:86720 antibody, AI448320 antibody, AW552119 antibody, FYN proto-oncogene, Src family tyrosine kinase antibody, FYN proto-oncogene, Src family tyrosine kinase S homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase b antibody, FYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, FYN proto-oncogene, Src family tyrosine kinase a antibody, Fyn proto-oncogene antibody, FYN antibody, fyn.S antibody, fynb antibody, fyn.L antibody, Fyn antibody, fyna antibody

Background:

Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

Aliases: SLK, SYN, MGC45350

Molecular Weight: 61kDa

Gene ID: 2534

HGNC: 2534

UniProt: P06241

Pathways: JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling