FES antibody (AA 613-822)

Catalog No. ABIN969134

Product Details anti-FES Antibody

Target: FES (Feline Sarcoma Oncogene (FES))

Binding Specificity: AA 613-822

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FES antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: FES Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of FES (AA:613-822)expressed in E. Coli.

Clone: 2E3G3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FES antibody (ABIN969134)

Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, (2006) (PubMed).

Durfee, Rivard: "Design and simulation of a pneumatic, stored-energy, hybrid orthosis for gait restoration." in: Journal of biomechanical engineering, Vol. 127, Issue 6, pp. 1014-9, (2006) (PubMed).

Vitenzon, Mironov, Petrushanskaya: "Functional electrostimulation of muscles as a method for restoring motor functions." in: Neuroscience and behavioral physiology, Vol. 35, Issue 7, pp. 709-14, (2006) (PubMed).

Target Details for FES

Target: FES (Feline Sarcoma Oncogene (FES))

Alternative Name: FES (FES Products)

Synonyms: FPS antibody, RGD1564385 antibody, AI586313 antibody, BB137047 antibody, c-fes antibody, FES antibody, c-fps antibody, FES proto-oncogene, tyrosine kinase antibody, feline sarcoma oncogene antibody, FES antibody, Fes antibody, fes antibody

Background:

Description: FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Aliases: FPS

Gene ID: 2242

HGNC: 2242

UniProt: P07332

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2