FER antibody

Catalog No. ABIN969133

Product Details anti-FER Antibody

Target: FER (FER Tyrosine Kinase (FER))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FER antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: FER Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FER expressed in E. Coli.

Clone: 5D2C4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FER antibody (ABIN969133)

Li, Cheng, Ling: "Isolation and characterization of Fe(III)-chelate reductase gene LeFRO1 in tomato." in: Plant molecular biology, Vol. 54, Issue 1, pp. 125-36, (2004) (PubMed).

Girault, Greengard: "The neurobiology of dopamine signaling." in: Archives of neurology, Vol. 61, Issue 5, pp. 641-4, (2004) (PubMed).

Fan, Di Ciano-Oliveira, Weed, Craig, Greer, Rotstein, Kapus: "Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase." in: The Biochemical journal, Vol. 380, Issue Pt 2, pp. 581-91, (2004) (PubMed).

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: FER (FER Products)

Synonyms: FerT antibody, PPP1R74 antibody, TYK3 antibody, Fer antibody, Flk antibody, Flk_retired antibody, AV082135 antibody, C330004K01Rik antibody, Fert antibody, FER tyrosine kinase antibody, fer (fms/fps related) protein kinase antibody, FER antibody, Fer antibody

Background:

Description: FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

Aliases: TYK3, FER

Molecular Weight: 95kDa

Gene ID: 2241

HGNC: 2241

UniProt: P16591