ETV4 antibody (AA 50-109)

Catalog No. ABIN969121

Product Details anti-ETV4 Antibody

Target: ETV4 (Ets Variant 4 (ETV4))

Binding Specificity: AA 50-109

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ETV4 antibody is un-conjugated

Application: ELISA

Purpose: ETV4 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.

Clone: 1A2G3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ETV4 antibody (ABIN969121)

Yu, Xia, Wang, Wang, Pan, Kwong, Hortobagyi, Hung: "Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1." in: Molecular carcinogenesis, Vol. 45, Issue 9, pp. 667-75, (2006) (PubMed).

Matsui, Sugimori, Motomura, Ejiri, Tsukada, Kitajima: "PEA3 cooperates with c-Jun in regulation of HER2/neu transcription." in: Oncology reports, Vol. 16, Issue 1, pp. 153-8, (2006) (PubMed).

Zhu, Jiang, Shen, Wang, Zong, Li, Yang, Niu, Liu, Chen, Hu, Gu: "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12503-16, (2005) (PubMed).

Target Details for ETV4

Target: ETV4 (Ets Variant 4 (ETV4))

Alternative Name: ETV4 (ETV4 Products)

Synonyms: E1A-F antibody, E1AF antibody, PEA3 antibody, PEAS3 antibody, Pea3 antibody, AW414408 antibody, Pea-3 antibody, pea3 antibody, ETS variant 4 antibody, ets variant 4 antibody, ETV4 antibody, Etv4 antibody, etv4 antibody

Background:

Description: ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.

Aliases: HGK, NIK, PEA3

Molecular Weight: 54kDa

Gene ID: 2118

HGNC: 2118

UniProt: P43268