ERN1 antibody (AA 282-433)

Catalog No. ABIN969116

Product Details anti-ERN1 Antibody

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Binding Specificity: AA 282-433

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purpose: ERN1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ERN1(aa282-433) expressed in E. Coli.

Clone: 9F2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ERN1 antibody (ABIN969116)

Lin, Li, Yasumura, Cohen, Zhang, Panning, Shokat, Lavail, Walter: "IRE1 signaling affects cell fate during the unfolded protein response." in: Science (New York, N.Y.), Vol. 318, Issue 5852, pp. 944-9, (2007) (PubMed).

Huang, Tan, Yoshida, Mori, Ma, Yen: "Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress." in: Molecular and cellular biology, Vol. 25, Issue 17, pp. 7522-33, (2005) (PubMed).

Shang, Lehrman: "Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts." in: Biochemical and biophysical research communications, Vol. 317, Issue 2, pp. 390-6, (2004) (PubMed).

Target Details for ERN1

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Alternative Name: ERN1 (ERN1 Products)

Background:

Description: The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Aliases: IRE1, IRE1P, IRE1a, hIRE1p, FLJ30999, MGC163277, MGC163279, ERN1

Molecular Weight: 109kDa

Gene ID: 2081

HGNC: 2081

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response