MAPK6 antibody
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- Target See all MAPK6 Antibodies
- MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This MAPK6 antibody is un-conjugated
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Application
- ELISA, Flow Cytometry (FACS)
- Purpose
- ERK3 Antibody
- Purification
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of human ERK3 expressed in E. Coli.
- Clone
- 4E8
- Isotype
- IgG1
- Top Product
- Discover our top product MAPK6 Primary Antibody
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 39, pp. 16710-5, (2009) (PubMed).
: "Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5." in: Journal of cellular physiology, Vol. 217, Issue 3, pp. 778-88, (2008) (PubMed).
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Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 39, pp. 16710-5, (2009) (PubMed).
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- Target
- MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))
- Alternative Name
- ERK3 (MAPK6 Products)
- Background
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Description: The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. (provided by RefSeq) Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts
Aliases: ERK3, PRKM6, p97MAPK, HsT17250, DKFZp686F03189, MAPK6
- Molecular Weight
- 105kDa
- Gene ID
- 5597
- HGNC
- 5597
- UniProt
- Q16659
- Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
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