EPH Receptor B3 antibody (AA 39-212)

Catalog No. ABIN969106

Product Details anti-EPH Receptor B3 Antibody

Target: EPH Receptor B3 (EPHB3)

Binding Specificity: AA 39-212

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EPH Receptor B3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: EphB3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of EphB3 (aa39-212) expressed in E. Coli.

Clone: 4A122D1

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EPH Receptor B3 antibody (ABIN969106)

Trivier, Ganesan: "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 23037-43, (2002) (PubMed).

Bergemann, Zhang, Chiang, Brambilla, Klein, Flanagan: "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube." in: Oncogene, Vol. 16, Issue 4, pp. 471-80, (1998) (PubMed).

Hock, Böhme, Karn, Yamamoto, Kaibuchi, Holtrich, Holland, Pawson, Rübsamen-Waigmann, Strebhardt: "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 17, pp. 9779-84, (1998) (PubMed).

Target Details for EPH Receptor B3

Target: EPH Receptor B3 (EPHB3)

Alternative Name: EphB3 (EPHB3 Products)

Synonyms: tck antibody, MGC83457 antibody, EPHB3 antibody, ETK2 antibody, HEK2 antibody, TYRO6 antibody, AW456895 antibody, Cek10 antibody, Etk2 antibody, MDK5 antibody, Sek4 antibody, Tyro6 antibody, CEK10 antibody, EK10 antibody, ek3 antibody, ephb3 antibody, fc62d03 antibody, rtk3 antibody, wu:fc62d03 antibody, zek3 antibody, EPH receptor B3 antibody, EPH receptor B3 L homeolog antibody, Eph receptor B3 antibody, eph receptor B3a antibody, Eph receptor tyrosine kinase antibody, EPHB3 antibody, ephb3.L antibody, ephb3 antibody, Ephb3 antibody, ephb3a antibody

Background:

Description: EphB3: EPH receptor B3. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Aliases: ETK2, HEK2, TYRO6

Gene ID: 2049

HGNC: 2049

UniProt: P54753

Pathways: RTK Signaling