DDR2 antibody

Catalog No. ABIN969083

Product Details anti-DDR2 Antibody

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DDR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: DDR2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human DDR2 expressed in E. Coli.

Clone: 3B11E4

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-DDR2 antibody (ABIN969083)

Leitinger, Kwan: "The discoidin domain receptor DDR2 is a receptor for type X collagen." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, (2006) (PubMed).

Shyu, Chao, Wang, Kuan: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." in: Hypertension, Vol. 46, Issue 3, pp. 614-21, (2005) (PubMed).

Neale, Kenny, Gershwin: "Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes." in: Clinical & developmental immunology, Vol. 11, Issue 2, pp. 157-63, (2004) (PubMed).

Target Details for DDR2

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Alternative Name: DDR2 (DDR2 Products)

Synonyms: MIG20a antibody, NTRKR3 antibody, TKT antibody, TYRO10 antibody, AW495251 antibody, Ntrkr3 antibody, tyro10 antibody, DDR2 antibody, Tyro10 antibody, ddr2 antibody, si:ch211-193c2.1 antibody, discoidin domain receptor tyrosine kinase 2 antibody, discoidin domain receptor family, member 2 antibody, discoidin domain receptor family, member 2, like antibody, DDR2 antibody, Ddr2 antibody, ddr2l antibody

Background:

Description: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Aliases: TKT, MIG20a, NTRKR3, TYRO10

Gene ID: 4921

HGNC: 4921

UniProt: Q16832

Pathways: RTK Signaling