COX IV antibody

Catalog No. ABIN969060

Product Details anti-COX IV Antibody

Target: COX IV (COX4I1) (Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COX IV antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: COX4I1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human COX4I1 expressed in E. Coli.

Clone: 6B3

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-COX IV antibody (ABIN969060)

Lithgow: "Targeting of proteins to mitochondria." in: FEBS letters, Vol. 476, Issue 1-2, pp. 22-6, (2000) (PubMed).

Romero, Marsac, Fardeau, Droste, Schneyder, Kadenbach: "Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle." in: Histochemistry, Vol. 94, Issue 2, pp. 211-5, (1990) (PubMed).

Target Details for COX IV

Target: COX IV (COX4I1) (Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1))

Alternative Name: COX4I1 (COX4I1 Products)

Background:

Description: Cytochrome c oxidase (COX) functions as the terminal oxidase of the respiratory chain that uses cytochrome c as an electron donor to drive a proton gradient across the inner mitochondrial membrane. The mammalian COX apoenzyme is a heteromer consisting of three mitochondrial encoded catalytic subunits and several nuclear gene encoded structural subunits. COX contains two iron-coordination sites and two copper-coordination sites. Cytochrome c oxidase IV (COX4) is a nuclear-encoded subunit of COX that may play a role in regulating COX activity. COX4 is expressed ubiquitously in adult human tissue with the strongest levels of expression in the pancreas and moderate expression levels in heart, skeletal muscle and placenta.

Aliases: COX4, COXIV, COX4-1, MGC72016, COX4I1

Molecular Weight: 19kDa

Gene ID: 1327

HGNC: 1327

UniProt: P13073

Pathways: Proton Transport