IKK alpha antibody (AA 500-590)

Catalog No. ABIN969054

Product Details anti-IKK alpha Antibody

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Binding Specificity: AA 500-590

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IKK alpha antibody is un-conjugated

Application: ELISA

Purpose: CHUK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.

Clone: 7C10B6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IKK alpha antibody (ABIN969054)

Prajapati, Verma, Yamamoto, Kwak, Gaynor: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, (2004) (PubMed).

Target Details for IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Alternative Name: CHUK (CHUK Products)

Synonyms: ikk antibody, ikk1 antibody, ikka antibody, ikkalpha antibody, CHUK antibody, IKBKA antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, NFKBIKA antibody, TCF16 antibody, AI256658 antibody, Chuk1 antibody, Fbx24 antibody, Fbxo24 antibody, Ikka antibody, zgc:56539 antibody, conserved helix-loop-helix ubiquitous kinase S homeolog antibody, conserved helix-loop-helix ubiquitous kinase antibody, chuk.S antibody, CHUK antibody, Chuk antibody, chuk antibody

Background:

Description: CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Aliases: IKK1, IKKA, IKBKA

Gene ID: 1147

HGNC: 1147

UniProt: O15111

Pathways: PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins