Chitotriosidase 1 antibody (AA 22-137)

Catalog No. ABIN969053

Product Details anti-Chitotriosidase 1 Antibody

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Binding Specificity: AA 22-137

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Chitotriosidase 1 antibody is un-conjugated

Application: ELISA

Purpose: CHIT1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of CHIT1 (aa22-137) expressed in E. Coli.

Clone: 1D9G2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Chitotriosidase 1 antibody (ABIN969053)

Wajner, Michelin, Burin, Pires, Pereira, Giugliani, Coelho et al.: "Comparison between the biochemical properties of plasma chitotriosidase from normal individuals and from patients with Gaucher disease, GM1-gangliosidosis, Krabbe disease and heterozygotes for ..." in: Clinical biochemistry, Vol. 40, Issue 5-6, pp. 365-9, (2007) (PubMed).

Bargagli, Margollicci, Perrone, Luddi, Perari, Bianchi, Refini, Grosso, Volterrani, Rottoli: "Chitotriosidase analysis in bronchoalveolar lavage of patients with sarcoidosis." in: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders, Vol. 24, Issue 1, pp. 59-64, (2007) (PubMed).

Target Details for Chitotriosidase 1

Target: Chitotriosidase 1 (CHIT1) (Chitotriosidase (CHIT1))

Alternative Name: CHIT1 (CHIT1 Products)

Synonyms: CHI3 antibody, CHIT antibody, CHITD antibody, CHIT1 antibody, chio antibody, 2300002L19Rik antibody, chitinase 1 antibody, chitinase 1 (chitotriosidase) antibody, CHIT1 antibody, chit1 antibody, Chit1 antibody

Background:

Description: CHIT1:chitinase 1 (chitotriosidase). Chitotriosidase is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

Aliases: Chitotriosidase,CHI3, CHIT, FLJ00314, MGC125322, CHIT1

Molecular Weight: 52kDa

Gene ID: 1118

HGNC: 1118

UniProt: Q13231