CHD3 antibody

Catalog No. ABIN969052

Product Details anti-CHD3 Antibody

Target: CHD3 (Chromodomain Helicase DNA Binding Protein 3 (CHD3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHD3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: CHD3 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CHD3 expressed in E. Coli.

Clone: 2G4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CHD3 antibody (ABIN969052)

Burd, Kinyamu, Miller, Archer: "UV radiation regulates Mi-2 through protein translation and stability." in: The Journal of biological chemistry, Vol. 283, Issue 50, pp. 34976-82, (2008) (PubMed).

Target Details for CHD3

Target: CHD3 (Chromodomain Helicase DNA Binding Protein 3 (CHD3))

Alternative Name: CHD3 (CHD3 Products)

Synonyms: CG9594 antibody, CHD-3 antibody, CHD3 antibody, DmCHD3 antibody, Dmel\\CG9594 antibody, chd3 antibody, dCHD3 antibody, LOC568230 antibody, zfh antibody, mi-2a antibody, mi2-alpha antibody, Mi-2a antibody, Mi2-ALPHA antibody, ZFH antibody, 2600010P09Rik antibody, AF020312 antibody, Chd7 antibody, Prp7 antibody, Prp9-1 antibody, CG9594 gene product from transcript CG9594-RA antibody, chromodomain helicase DNA binding protein 3 antibody, chromodomain-helicase-DNA-binding protein 3 antibody, Chd3 antibody, CHD3 antibody, chd3 antibody, LOC100480350 antibody

Background:

Description: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Aliases: ZFH, Mi-2a, Mi2-ALPHA, CHD3

Molecular Weight: 226kDa

Gene ID: 1107

HGNC: 1107

UniProt: Q12873