CD40 antibody

Catalog No. ABIN969025

Product Details anti-CD40 Antibody

Target: CD40

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD40 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: CD40 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of CD40 expressed in E. Coli.

Clone: 9G10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD40 antibody (ABIN969025)

Linderoth, Jerkeman, Cavallin-Ståhl, Kvaløy, Torlakovic: "Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 722-8, (2003) (PubMed).

Hakkarainen, Hemminki, Pereboev, Barker, Asiedu, Strong, Kanerva, Wahlfors, Curiel: "CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 2, pp. 619-24, (2003) (PubMed).

Target Details for CD40

Target: CD40

Alternative Name: CD40 (CD40 Products)

Synonyms: Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody

Background:

Description: CD40 Molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Aliases: p50, Bp50, CDW40, TNFRSF5

Molecular Weight: 30.6kDa

Gene ID: 958

HGNC: 958

UniProt: P25942

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints