CD276 antibody

Catalog No. ABIN969018

Product Details anti-CD276 Antibody

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC)

Purpose: CD276 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CD276 expressed in E. Coli.

Clone: 6A1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD276 antibody (ABIN969018)

Zhang, Dong, Xu, Yu, Zhang: "B7-H3: another molecule marker for Mo-DCs?" in: Cellular & molecular immunology, Vol. 2, Issue 4, pp. 307-11, (2005) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Target Details for CD276

Target: CD276

Alternative Name: CD276 (CD276 Products)

Synonyms: sc:d0645 antibody, zgc:158279 antibody, 6030411F23Rik antibody, AU016588 antibody, B7RP-2 antibody, B7h3 antibody, B7H3 antibody, 4Ig-B7-H3 antibody, B7-H3 antibody, CD276 molecule antibody, CD276 molecule S homeolog antibody, CD276 antigen antibody, Cd276 molecule antibody, CD276 antibody, cd276.S antibody, cd276 antibody, Cd276 antibody

Background:

Description: Costimulatory B7 Molecules (e.g., B7-1, or CD80, MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558). May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Aliases: B7H3, B7-H3, 4Ig-B7-H3, CD276

Molecular Weight: 57kDa

Gene ID: 80381

HGNC: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints