BMX antibody

Catalog No. ABIN968989

Product Details anti-BMX Antibody

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BMX antibody is un-conjugated

Application: ELISA

Purpose: BMX Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human BMX expressed in E. Coli.

Clone: 1C6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-BMX antibody (ABIN968989)

Palmer, Mutch, Workman, McDaid, Horwood, Foxwell: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, (2008) (PubMed).

Côté, Motoyama, Bush, Vuori: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, (2005) (PubMed).

Target Details for BMX

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Alternative Name: BMX (BMX Products)

Synonyms: BMX antibody, ETK antibody, PSCTK2 antibody, PSCTK3 antibody, Etk antibody, Etk/Bmx antibody, Tyro8 antibody, RGD1565643 antibody, BMX non-receptor tyrosine kinase antibody, BMX antibody, bmx antibody, Bmx antibody

Background:

Description: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Aliases: ETK, PSCTK2, PSCTK3, BMX

Molecular Weight: 78kDa

Gene ID: 660

HGNC: 660

UniProt: P51813