AXL antibody

Catalog No. ABIN968974

Product Details anti-AXL Antibody

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AXL antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Purpose: AXL Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line.

Clone: 7E10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-AXL antibody (ABIN968974)

Vajkoczy, Knyazev, Kunkel, Capelle, Behrndt, von Tengg-Kobligk, Kiessling, Eichelsbacher, Essig, Read, Erber, Ullrich: "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 15, pp. 5799-804, (2006) (PubMed).

Target Details for AXL

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Alternative Name: AXL (AXL Products)

Synonyms: JTK11 antibody, UFO antibody, AI323647 antibody, Ark antibody, Tyro7 antibody, Ufo antibody, AXL receptor tyrosine kinase antibody, Axl receptor tyrosine kinase antibody, AXL antibody, Axl antibody

Background:

Description: AXL: AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

Aliases: UFO, JTK11

Molecular Weight: 97.4kDa

Gene ID: 558

HGNC: 558

UniProt: P30530

Pathways: RTK Signaling, Cellular Response to Molecule of Bacterial Origin