ARNTL antibody

Catalog No. ABIN968967

Product Details anti-ARNTL Antibody

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARNTL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: ARNTL Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ARNTL expressed in E. Coli.

Clone: 1C5

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ARNTL antibody (ABIN968967)

Yosifova, Mushiroda, Stoianov, Vazharova, Dimova, Karachanak, Zaharieva, Milanova, Madjirova, Gerdjikov, Tolev, Velkova, Kirov, Owen, ODonovan, Toncheva, Nakamura: "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population." in: Journal of affective disorders, Vol. 117, Issue 1-2, pp. 87-97, (2009) (PubMed).

Lee, Lee, Lee, Park, Kang, Chung, Lee, Kim: "Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 6056-65, (2008) (PubMed).

Motzkus, Loumi, Cadenas, Vinson, Forssmann, Maronde: "Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways." in: Chronobiology international, Vol. 24, Issue 5, pp. 783-92, (2007) (PubMed).

Target Details for ARNTL

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Alternative Name: ARNTL (ARNTL Products)

Synonyms: BMAL1 antibody, BMAL1c antibody, JAP3 antibody, MOP3 antibody, PASD3 antibody, TIC antibody, bHLHe5 antibody, Bmal1 antibody, ARNTL antibody, xBmal1 antibody, arntl antibody, Arnt3 antibody, BMAL1b antibody, bmal1b' antibody, aryl hydrocarbon receptor nuclear translocator like antibody, aryl hydrocarbon receptor nuclear translocator-like antibody, aryl hydrocarbon receptor nuclear translocator like S homeolog antibody, ARNTL antibody, Arntl antibody, arntl.S antibody, arntl antibody

Background:

Description: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.

Aliases: TIC, JAP3, MOP3, BMAL1, PASD3, BMAL1c, bHLHe5, MGC47515, ARNTL

Molecular Weight: 68.7kDa

Gene ID: 406

HGNC: 406

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effect