APOB antibody

Catalog No. ABIN968961

Product Details anti-APOB Antibody

Target: APOB (Apolipoprotein B (APOB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOB antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: ApoB Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ApoB expressed in E. Coli.

Clone: 6G6

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-APOB antibody (ABIN968961)

Benn: "Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review." in: Atherosclerosis, Vol. 206, Issue 1, pp. 17-30, (2009) (PubMed).

Peterson, Mack, Hall, Alsup, Alexander, Sully, Sawires, Cheung, Otto, Gresham: "Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection." in: Cell host & microbe, Vol. 4, Issue 6, pp. 555-66, (2008) (PubMed).

Target Details for APOB

Target: APOB (Apolipoprotein B (APOB))

Alternative Name: ApoB (APOB Products)

Synonyms: FLDB antibody, LDLCQ4 antibody, Ac1-060 antibody, Apo B-100 antibody, ApoB-100 antibody, ApoB-48 antibody, AI315052 antibody, apob-100 antibody, apob-48 antibody, APOB-100 antibody, ApoB(100) antibody, APOB antibody, apolipoprotein B antibody, APOB antibody, Apob antibody

Background:

Description: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

Aliases: FLDB, LDLCQ4

Molecular Weight: 516kDa

Gene ID: 338

HGNC: 338

UniProt: P04114

Pathways: Lipid Metabolism