Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Sortilin 1 antibody (AA 300-422)

SORT1 Reactivity: Human, Rat, Mouse, Dog, Chicken WB, IF Host: Mouse Monoclonal 48-Neurotensin Receptor 3 unconjugated
Catalog No. ABIN968738
  • Target See all Sortilin 1 (SORT1) Antibodies
    Sortilin 1 (SORT1)
    Binding Specificity
    • 16
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 300-422
    Reactivity
    • 44
    • 37
    • 31
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Dog, Chicken
    Host
    • 47
    • 5
    • 2
    Mouse
    Clonality
    • 50
    • 4
    Monoclonal
    Conjugate
    • 24
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sortilin 1 antibody is un-conjugated
    Application
    • 37
    • 18
    • 17
    • 13
    • 13
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Neurotensin Receptor 3 aa. 300-422
    Clone
    48-Neurotensin Receptor 3
    Isotype
    IgG1
    Top Product
    Discover our top product SORT1 Primary Antibody
  • Comment

    Related Products: ABIN968700, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Nielsen, Jacobsen, Olivecrona, Gliemann, Petersen: "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8832-6, (1999) (PubMed).

    Mazella, Zsürger, Navarro, Chabry, Kaghad, Caput, Ferrara, Vita, Gully, Maffrand, Vincent: "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26273-6, (1998) (PubMed).

    Morris, Ross, Lane, Moestrup, Petersen, Keller, Lienhard: "Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes." in: The Journal of biological chemistry, Vol. 273, Issue 6, pp. 3582-7, (1998) (PubMed).

  • Target
    Sortilin 1 (SORT1)
    Alternative Name
    Neurotensin Receptor 3 (SORT1 Products)
    Synonyms
    SORT1 antibody, 19.m02079 antibody, gp95 antibody, ldlcq6 antibody, sortilin antibody, Gp95 antibody, LDLCQ6 antibody, NT3 antibody, 2900053A11Rik antibody, AI852375 antibody, Ntr3 antibody, Ntsr3 antibody, Nt3 antibody, Nts3 antibody, sort1 antibody, zgc:85953 antibody, sortilin 1 antibody, sortilin antibody, sortilin 1 S homeolog antibody, sortilin 1a antibody, SORT1 antibody, TP01_0016 antibody, BBOV_I002730 antibody, sort1.S antibody, Sort1 antibody, sort1a antibody
    Background
    Neurotensin (NT) is a neuropeptide that modulates dopaminergic transmission, triggers analgesic responses, induces hypotension, decreases gastric acid secretion, and activates lipid digestion. NT is a ligand for NT receptors, which include both G-protein coupled and non-G-protein coupled receptors. Neurotensin Receptor 3 (NTR3) is a non-G-protein coupled receptor that has a lumenal domain homologous to sorting proteins, and a short cytoplasmic tail homologous to mannose-6-phosphate/IGF-II receptor. NTR3 was also identified as sortilin/gp95, a component of GLUT4 vesicles in adipocytes that has been implicated in lipoprotein lipase degradation. NTR3 mRNA is expressed in brain, skeletal muscle, heart, and adipocytes. NTR3 mature protein has 44 N-terminal amino acid residues cleaved off, which may facilitate ligand binding to the receptor. Cellular localization of NTR3 is in the Golgi compartment and vesicles, as well as on the cell surface. In addition to roles in neuropeptide and lipoprotein degradation, NTR3 may also be involved in receptor protein sorting. Thus, NTR3 is a multifunctional transmembrane protein that acts as both a intracellular sorting receptor and extracellular ligand-binding receptor.
    Synonyms: NTR3
    Molecular Weight
    95 kDa
    Pathways
    Neurotrophin Signaling Pathway
You are here:
Support