KIF1A antibody (AA 902-1015)

Catalog No. ABIN968736

Product Details anti-KIF1A Antibody

Target: KIF1A (Kinesin Family Member 1A (KIF1A))

Binding Specificity: AA 902-1015

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIF1A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse KIF1A aa. 902-1015

Clone: 16-KIF1A

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-KIF1A antibody (ABIN968736)

Bloom: "The UNC-104/KIF1 family of kinesins." in: Current opinion in cell biology, Vol. 13, Issue 1, pp. 36-40, (2001) (PubMed).

Yonekawa, Harada, Okada, Funakoshi, Kanai, Takei, Terada, Noda, Hirokawa: "Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice." in: The Journal of cell biology, Vol. 141, Issue 2, pp. 431-41, (1998) (PubMed).

Okada, Yamazaki, Sekine-Aizawa, Hirokawa: "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors." in: Cell, Vol. 81, Issue 5, pp. 769-80, (1995) (PubMed).

Target Details for KIF1A

Target: KIF1A (Kinesin Family Member 1A (KIF1A))

Alternative Name: KIF1A (KIF1A Products)

Synonyms: ATSV antibody, C630002N23Rik antibody, Gm1626 antibody, Kns1 antibody, C2orf20 antibody, HSN2C antibody, MRD9 antibody, SPG30 antibody, UNC104 antibody, kinesin family member 1A antibody, kinesin family member 1Aa antibody, KIF1A antibody, kif1a antibody, Kif1a antibody, kif1aa antibody

Background: The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF1A/1B, KIF3A/3B, KRP85/95, and Klp68d/64. KIF1A and KIF1B are 93% homologous in their N-terminal motor domains, however KIF1A contains a C-terminal PH domain. KIF1A and KIF1B are expressed in neurons where KIF1A is involved in fast anterograde axon transport of synaptic vesicles, and KIF1B is involved in anterograde axon transport of mitochondria. KIF1A associates with organelles that contain synaptotagmin, synaptophysin, and Rab3A. Disruption of the KIF1A gene in mice causes decreases in synaptic vesicle density, neuronal degeneration, and deficits in motor and sensory function. Thus, KIF1A is a critical brain motor protein involved with axonal transport of synaptic vesicle precursors. This antibody is routinely tested by western blot analysis.

Molecular Weight: 200 kDa