CTBP2 antibody (AA 361-445)

Catalog No. ABIN968723

Product Details anti-CTBP2 Antibody

Target: CTBP2 (C-terminal Binding Protein 2 (CTBP2))

Binding Specificity: AA 361-445

Reactivity: Human, Mouse, Rat, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTBP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus), Human, Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse CtBP2 aa. 361-445

Clone: 16-CtBP2

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-CTBP2 antibody (ABIN968723)

De Sevilla Müller, Liu, Solomon, Rodriguez, Brecha: "Expression of voltage-gated calcium channel α(2)δ(4) subunits in the mouse and rat retina." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2486-501, (2013) (PubMed).

Hoshi, Tian, Massey, Mills: "Properties of the ON bistratified ganglion cell in the rabbit retina." in: The Journal of comparative neurology, Vol. 521, Issue 7, pp. 1497-509, (2013) (PubMed).

Koizumi, Jakobs, Masland: "Regular mosaic of synaptic contacts among three retinal neurons." in: The Journal of comparative neurology, Vol. 519, Issue 2, pp. 341-57, (2011) (PubMed).

Blazquez-Llorca, García-Marín, DeFelipe: "GABAergic complex basket formations in the human neocortex." in: The Journal of comparative neurology, Vol. 518, Issue 24, pp. 4917-37, (2011) (PubMed).

Hilgen, von Maltzahn, Willecke, Weiler, Dedek: "Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina." in: The Journal of comparative neurology, Vol. 519, Issue 3, pp. 433-50, (2011) (PubMed).

Percival, Jusuf, Martin, Grünert: "Synaptic inputs onto small bistratified (blue-ON/yellow-OFF) ganglion cells in marmoset retina." in: The Journal of comparative neurology, Vol. 517, Issue 5, pp. 655-69, (2010) (PubMed).

Hendrickson, Troilo, Djajadi, Possin, Springer: "Expression of synaptic and phototransduction markers during photoreceptor development in the marmoset monkey Callithrix jacchus." in: The Journal of comparative neurology, Vol. 512, Issue 2, pp. 218-31, (2009) (PubMed).

Taylor, Peleshok, Ribeiro-da-Silva: "Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat." in: The Journal of comparative neurology, Vol. 514, Issue 6, pp. 555-66, (2009) (PubMed).

Hoshi, Mills: "Components and properties of the G3 ganglion cell circuit in the rabbit retina." in: The Journal of comparative neurology, Vol. 513, Issue 1, pp. 69-82, (2009) (PubMed).

Regus-Leidig, Tom Dieck, Specht, Meyer, Brandstätter: "Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: the involvement of precursor spheres." in: The Journal of comparative neurology, Vol. 512, Issue 6, pp. 814-24, (2008) (PubMed).

Raven, Orton, Nassar, Williams, Stell, Jacobs, Bech-Hansen, Reese: "Early afferent signaling in the outer plexiform layer regulates development of horizontal cell morphology." in: The Journal of comparative neurology, Vol. 506, Issue 5, pp. 745-58, (2008) (PubMed).

Jakobs, Koizumi, Masland: "The spatial distribution of glutamatergic inputs to dendrites of retinal ganglion cells." in: The Journal of comparative neurology, Vol. 510, Issue 2, pp. 221-36, (2008) (PubMed).

Lee, Grünert: "Connections of diffuse bipolar cells in primate retina are biased against S-cones." in: The Journal of comparative neurology, Vol. 502, Issue 1, pp. 126-40, (2007) (PubMed).

Wahlin, Moreira, Huang, Yu, Adler: "Molecular dynamics of photoreceptor synapse formation in the developing chick retina." in: The Journal of comparative neurology, Vol. 506, Issue 5, pp. 822-37, (2007) (PubMed).

Quraishi, Gayet, Morgans, Duvoisin: "Distribution of group-III metabotropic glutamate receptors in the retina." in: The Journal of comparative neurology, Vol. 501, Issue 6, pp. 931-43, (2007) (PubMed).

Puller, Haverkamp, Grünert: "OFF midget bipolar cells in the retina of the marmoset, Callithrix jacchus, express AMPA receptors." in: The Journal of comparative neurology, Vol. 502, Issue 3, pp. 442-54, (2007) (PubMed).

Pan, Massey: "Rod and cone input to horizontal cells in the rabbit retina." in: The Journal of comparative neurology, Vol. 500, Issue 5, pp. 815-31, (2007) (PubMed).

Bayley, Morgans: "Rod bipolar cells and horizontal cells form displaced synaptic contacts with rods in the outer nuclear layer of the nob2 retina." in: The Journal of comparative neurology, Vol. 500, Issue 2, pp. 286-98, (2006) (PubMed).

Hildebrand, Soriano: "Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5296-307, (2002) (PubMed).

Muraoka, Ichikawa, Shi, Okumura, Taira, Higuchi, Hirano, Hibi, Miki: "Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio)." in: Developmental biology, Vol. 228, Issue 1, pp. 29-40, (2001) (PubMed).

Target Details for CTBP2

Target: CTBP2 (C-terminal Binding Protein 2 (CTBP2))

Alternative Name: CtBP2 (CTBP2 Products)

Synonyms: ctbp antibody, ctbp-b antibody, xctbp antibody, AA407280 antibody, D7Ertd45e antibody, Gtrgeo6 antibody, Ribeye antibody, fe05b01 antibody, wu:fb96g03 antibody, wu:fe05b01 antibody, wu:fk19e02 antibody, C-terminal binding protein 2 antibody, C-terminal-binding protein 2 antibody, C-terminal binding protein 2a antibody, C-terminal binding protein 2 S homeolog antibody, ctbp2 antibody, LOC100398309 antibody, CTBP2 antibody, Ctbp2 antibody, ctbp2a antibody, ctbp2.S antibody

Background: Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a co-repressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of co-repressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the deltaEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in deltaEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important co-repressors for a variety of transcriptional factors. This antibody is routinely tested by western blot analysis.
Synonyms: C-Terminal Binding Protein-2

Molecular Weight: 48 kDa