SORL1 antibody (AA 1220-1337)
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- Target See all SORL1 Antibodies
- SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))
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Binding Specificity
- AA 1220-1337
- Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SORL1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Cross-Reactivity
- Rat (Rattus), Mouse (Murine)
- Characteristics
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human LR11 aa. 1220-1337
- Clone
- 48-LR11
- Isotype
- IgG2a
- Top Product
- Discover our top product SORL1 Primary Antibody
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- Comment
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Related Products: ABIN968545, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store undiluted at -20°C.
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Uptake of lipoproteins for axonal growth of sympathetic neurons." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19883-90, (2000) (PubMed).
: "Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31379-83, (1997) (PubMed).
: "Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24761-8, (1996) (PubMed).
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Uptake of lipoproteins for axonal growth of sympathetic neurons." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19883-90, (2000) (PubMed).
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- Target
- SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))
- Alternative Name
- LR11 (SORL1 Products)
- Synonyms
- SORL1 antibody, C11orf32 antibody, LR11 antibody, LRP9 antibody, SORLA antibody, SorLA-1 antibody, gp250 antibody, SorLA antibody, 2900010L19Rik antibody, AI596264 antibody, AW261561 antibody, mSorLA antibody, Lr11 antibody, RGD619914 antibody, sortilin related receptor 1 antibody, sortilin-related receptor antibody, sortilin-related receptor, L(DLR class) A repeats containing antibody, sortilin-related receptor, L(DLR class) A repeats-containing antibody, sortilin-related receptor, LDLR class A repeats-containing antibody, sorl1 antibody, LOC582560 antibody, SORL1 antibody, Sorl1 antibody
- Background
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The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia. Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor YWTDrepeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development.
Synonyms: SorLA, gp250, Lipoprotein Receptor-11 - Molecular Weight
- 250 kDa
- Pathways
- Smooth Muscle Cell Migration
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