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MPDZ antibody (AA 65-247)

MPDZ Reactivity: Mouse, Rat WB, IF Host: Mouse Monoclonal 43-MUPP1 unconjugated
Catalog No. ABIN968588
  • Target See all MPDZ Antibodies
    MPDZ (Multiple PDZ Domain Protein (MPDZ))
    Binding Specificity
    • 16
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 65-247
    Reactivity
    • 24
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Mouse, Rat
    Host
    • 24
    Mouse
    Clonality
    • 24
    Monoclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MPDZ antibody is un-conjugated
    Application
    • 14
    • 13
    • 13
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat MUPP1 aa. 65-247
    Clone
    43-MUPP1
    Isotype
    IgG1
    Top Product
    Discover our top product MPDZ Primary Antibody
  • Comment

    Related Products: ABIN967389, ABIN968545

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

    Ullmer, Schmuck, Figge, Lübbert: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, (1998) (PubMed).

  • Target
    MPDZ (Multiple PDZ Domain Protein (MPDZ))
    Alternative Name
    MUPP1 (MPDZ Products)
    Synonyms
    HYC2 antibody, MUPP1 antibody, AI225843 antibody, B930003D11Rik antibody, multiple PDZ domain crumbs cell polarity complex component antibody, multiple PDZ domain protein antibody, Multiple PDZ domain protein antibody, inactivation-no-after-potential D protein antibody, multiple pdz domain protein, putative antibody, MPDZ antibody, Mpdz antibody, mpz-1 antibody, LOC5569990 antibody, Smp_168960 antibody
    Background
    The postsynaptic density protein PSD-95 interacts with the cytoplasmic tail of ion channel subunits via a protein-protein motif called the PDZ domain. PSD-95 belongs to a family of PDZ domain-containing proteins that includes SAP97/Dlg, PSD-93/chapsyn-110, and SAP102. These proteins are characterized by three PDZ domains in the N-terminal half and an SH3 and guanylate kinase-like domain in the C-terminal region. They may be involved in the localization and clustering of ion channels and receptors at synaptic sites. Other PDZ domain-containing proteins such as glutamate receptor interacting protein (GRIP), Homer, and multi-PDZ-domain protein (MUPP1) do not contain guanylate kinase-like domains, but have also been implicated in receptor localization. MUPP1 contains thirteen PDZ domains and is expressed in human heart, brain, placenta, liver, skeletal muscle, kidney, and pancreas. In addition, smaller variants of MUPP1 are expressed in heart, liver, kidney, and brain. The C-terminal region of the 5-HT2c receptor interacts with MUPP1, suggesting that MUPP1 may have important protein-protein interactions during G-protein coupled receptor signaling.
    Molecular Weight
    219 kDa
    Pathways
    Synaptic Membrane, Phototransduction
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