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NPAT antibody (AA 681-803)

NPAT Reactivity: Human WB, IF Host: Mouse Monoclonal 27-NPAT unconjugated
Catalog No. ABIN968484
  • Target See all NPAT Antibodies
    NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))
    Binding Specificity
    • 2
    • 2
    AA 681-803
    Reactivity
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 5
    • 2
    Mouse
    Clonality
    • 5
    • 2
    Monoclonal
    Conjugate
    • 7
    This NPAT antibody is un-conjugated
    Application
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human NPAT aa. 681-803
    Clone
    27-NPAT
    Isotype
    IgG2b
    Top Product
    Discover our top product NPAT Primary Antibody
  • Comment

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Zhao, Dynlacht, Imai, Hori, Harlow: "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry." in: Genes & development, Vol. 12, Issue 4, pp. 456-61, (1998) (PubMed).

  • Target
    NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))
    Alternative Name
    NPAT (NPAT Products)
    Synonyms
    NPAT-like antibody, im:6901964 antibody, DKFZp469B186 antibody, 6820401K01 antibody, AI427561 antibody, BB112559 antibody, E14 antibody, E14/NPAT antibody, p220 antibody, nuclear protein, co-activator of histone transcription antibody, nuclear protein, coactivator of histone transcription antibody, protein NPAT antibody, nuclear protein, ataxia-telangiectasia locus antibody, nuclear protein in the AT region antibody, nuclear protein, ataxia-telangiectasia locus S homeolog antibody, Npat antibody, NPAT antibody, LOC489420 antibody, npat antibody, LOC100286556 antibody, LOC100402032 antibody, LOC100480887 antibody, LOC100540521 antibody, LOC100561473 antibody, LOC100627195 antibody, npat.S antibody
    Background
    Cyclins regulate transitions between cell cycle phases by acting as regulatory subunits of the cyclin-dependent kinases (cdk). The temporal expression of cyclins is tightly regulated and plays a critical role in controlling the enzymatic activity of the cdks. Cyclin-dependent kinase 2 (Cdk2) is a member of a family of cdc2-related cell cycle protein kinases. Cdk2 is expressed earlier in the cell cycle than cdc2 and forms complexes with cyclins A, E, D1, and D3. It is not known if the D cyclins can form active complexes with Cdk2. Cyclin E-Cdk2 kinase is active in the G1 and S phases of the cell cycle and is important, as is Cyclin A-Cdk2, for the progression from G1 to S phase. One substrate for cyclin E-Cdk2 is a Nuclear Protein mapped to the Ataxia Telangiectasia locus, NPAT. This protein associates with cyclin E-Cdk2 and can be phosphorylated by Cdk2. NPAT protein levels peak at the G1/S boundary and overexpression of NPAT accelerates S phase entry, especially after coexpression of cyclin E-Cdk2. Thus, NPAT is a substrate of cyclin E-Cdk2 that may mediate G1 to S phase transition.
    Synonyms: Nuclear Protein Ataxia Telangiectasia
    Molecular Weight
    210 kDa
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