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NCOA3 antibody (AA 376-389)

NCOA3 Reactivity: Human, Mouse, Rat WB, IF Host: Mouse Monoclonal 34-AIB unconjugated
Catalog No. ABIN968368
  • Target See all NCOA3 Antibodies
    NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
    Binding Specificity
    • 15
    • 14
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 376-389
    Reactivity
    • 61
    • 16
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 55
    • 7
    • 1
    • 1
    Mouse
    Clonality
    • 58
    • 6
    Monoclonal
    Conjugate
    • 33
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NCOA3 antibody is un-conjugated
    Application
    • 38
    • 24
    • 13
    • 13
    • 11
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human AIB-1 aa. 376-389
    Clone
    34-AIB
    Isotype
    IgG1
    Top Product
    Discover our top product NCOA3 Primary Antibody
  • Comment

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Louie, Yang, Ma, Xu, Zou, Kung, Chen: "Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2226-30, (2003) (PubMed).

    Lauritsen, List, Reiter, Wellstein, Riegel: "A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells." in: Oncogene, Vol. 21, Issue 47, pp. 7147-55, (2002) (PubMed).

    Reiter, Wellstein, Riegel: "An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39736-41, (2001) (PubMed).

    Eng, Barsalou, Akutsu, Mercier, Zechel, Mader, White: "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 28371-7, (1998) (PubMed).

    Anzick, Kononen, Walker, Azorsa, Tanner, Guan, Sauter, Kallioniemi, Trent, Meltzer: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 965-8, (1997) (PubMed).

  • Target
    NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
    Alternative Name
    AIB-1 (NCOA3 Products)
    Synonyms
    NCOA3 antibody, ACTR antibody, AIB-1 antibody, AIB1 antibody, CAGH16 antibody, CTG26 antibody, KAT13B antibody, RAC3 antibody, SRC-3 antibody, SRC3 antibody, TNRC14 antibody, TNRC16 antibody, TRAM-1 antibody, bHLHe42 antibody, pCIP antibody, 2010305B15Rik antibody, AW321064 antibody, Actr antibody, Aib1 antibody, Rac3 antibody, Src3 antibody, Tram-1 antibody, Tram1 antibody, p/Cip antibody, pCip antibody, actr antibody, aib-1 antibody, aib1 antibody, cagh16 antibody, ctg26 antibody, kat13b antibody, pcip antibody, rac3 antibody, src-3 antibody, src3 antibody, tnrc14 antibody, tnrc16 antibody, tram-1 antibody, xSRC-3 antibody, nuclear receptor coactivator 3 antibody, nuclear receptor coactivator 3 S homeolog antibody, NCOA3 antibody, Ncoa3 antibody, ncoa3.S antibody
    Background
    Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear hormone receptors are ligand-activated transcription factors that modulate target gene expression. These ligand/receptor complexes also interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified, including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1alpha and -1beta. AIB-1 (Amplified In Breast cancer-1) is also known as pCIP, RAC3, and TRAM-1. It interacts with estrogen receptor (ER) and is overexpressed in breast cancer biopsies and several breast and ovarian cancer cell lines. Similar to SRC-1 and TIF2, AIB-1 contains a basic helix-loop-helix (bHLH) domain followed by a PAS (Per/Arnt/Sim) region, serine and threonine rich regions, and a charged cluster. In addition, AIB-1 contains three copies of the conserved LXXLL motif which is critical to its interaction with the nuclear receptor. Thus, AIB-1 is a coactivator of nuclear receptors that may participate in the development of steroid-dependent cancers.
    Synonyms: Amplified In Breast cancer-1, pCIP, RAC3, TRAM-1
    Molecular Weight
    160 kDa
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha
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