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CDH15 antibody (AA 253-366)

CDH15 Reactivity: Mouse, Rat WB, IF Host: Mouse Monoclonal 5-M unconjugated
Catalog No. ABIN968363
  • Target See all CDH15 Antibodies
    CDH15 (M-Cadherin (CDH15))
    Binding Specificity
    • 15
    • 13
    • 7
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 253-366
    Reactivity
    • 51
    • 18
    • 13
    Mouse, Rat
    Host
    • 48
    • 4
    • 3
    • 2
    Mouse
    Clonality
    • 51
    • 6
    Monoclonal
    Conjugate
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CDH15 antibody is un-conjugated
    Application
    • 45
    • 31
    • 17
    • 13
    • 13
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse M-Cadherin aa. 253-366
    Clone
    5-M
    Isotype
    IgG2a
    Top Product
    Discover our top product CDH15 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Kang, Feinleib, Knox, Ketteringham, Krauss: "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 7, pp. 3989-94, (2003) (PubMed).

    Kaufmann, Kirsch, Irintchev, Wernig, Starzinski-Powitz: "The M-cadherin catenin complex interacts with microtubules in skeletal muscle cells: implications for the fusion of myoblasts." in: Journal of cell science, Vol. 112 ( Pt 1), pp. 55-68, (1999) (PubMed).

    Shimoyama, Shibata, Kitajima, Hirohashi: "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin." in: The Journal of biological chemistry, Vol. 273, Issue 16, pp. 10011-8, (1998) (PubMed).

    Kuch, Winnekendonk, Butz, Unvericht, Kemler, Starzinski-Powitz: "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells." in: Experimental cell research, Vol. 232, Issue 2, pp. 331-8, (1997) (PubMed).

    Donalies, Cramer, Ringwald, Starzinski-Powitz: "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 18, pp. 8024-8, (1991) (PubMed).

  • Target
    CDH15 (M-Cadherin (CDH15))
    Alternative Name
    M-Cadherin (CDH15 Products)
    Synonyms
    AI323380 antibody, Cdh14 antibody, Mcad antibody, CDH14 antibody, CDH3 antibody, CDHM antibody, MCAD antibody, MRD3 antibody, cadherin 15 antibody, Cdh15 antibody, CDH15 antibody
    Background
    Cadherins are a family of transmembrane glycoproteins involved in the Ca2+-dependent cell-cell adhesion that occurs in many tissues. Members of this family include P-Cadherin, E-Cadherin (uvomorulin), N-Cadherin, R-Cadherin, Cadherin-5, L-CAM, and EP-Cadherin. These proteins are similar in their domain structure (45-74% amino acid conservation), Ca2+ and protease sensitivity, and molecular weight. However, cadherins have distinct tissue expression patterns and immunological reactivities. M (muscle)-Cadherin, another member of the Cadherin family, was discovered in myogenic mouse cells where it is present at low levels in myoblasts. It is expressed in prenatal and adult skeletal muscle and plays a role in skeletal muscle cell differentiation, particularly the fusion of myoblasts into myotubes. It is upregulated upon induction of myotube formation. M-Cadherin also forms complexes with the catenins in skeletal muscle cells, which then interact with the cytoskeleton. Therefore, it is thought that the M-Cadherin-cytoskeleton interaction may play a role in aligning myoblasts during fusion. This antibody is routinely tested by western blot analysis.
    Molecular Weight
    130 kDa
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