ITGA3 antibody (AA 110-325)

Catalog No. ABIN968338

Product Details anti-ITGA3 Antibody

Target: ITGA3 (Integrin, alpha 3 (ITGA3))

Binding Specificity: AA 110-325

Reactivity: Mouse, Rat, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus), Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse VLA-3alpha aa. 110-325

Clone: 42-CD49c

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968547, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-ITGA3 antibody (ABIN968338)

Takeuchi, Hirano, Tsuji, Osawa, Irimura: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).

Takada, Murphy, Pil, Chen, Ginsberg, Hemler: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." in: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, (1991) (PubMed).

Target Details for ITGA3

Target: ITGA3 (Integrin, alpha 3 (ITGA3))

Alternative Name: CD49c (ITGA3 Products)

Synonyms: CD49C antibody, GAP-B3 antibody, GAPB3 antibody, ILNEB antibody, MSK18 antibody, VCA-2 antibody, VL3A antibody, VLA3a antibody, ITGA3 antibody, AA407068 antibody, integrin subunit alpha 3 antibody, integrin subunit alpha 3 S homeolog antibody, integrin alpha 3 antibody, ITGA3 antibody, itga3.S antibody, Itga3 antibody

Background: Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
Synonyms: Integrin alpha3, VLA-3alpha

Molecular Weight: 135 kDa

Pathways: CXCR4-mediated Signaling Events, Integrin Complex