LAMP1 antibody (AA 25-224)
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- Target See all LAMP1 Antibodies
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
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Binding Specificity
- AA 25-224
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This LAMP1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
- Characteristics
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human Lamp-1 aa. 25-224
- Clone
- 25-Lamp
- Isotype
- IgG2b
- Top Product
- Discover our top product LAMP1 Primary Antibody
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- Comment
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Related Products: ABIN968587, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store undiluted at -20° C.
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Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 659-68, (2002) (PubMed).
: "A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility." in: The Journal of cell biology, Vol. 158, Issue 1, pp. 175-84, (2002) (PubMed).
: "Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48858-67, (2002) (PubMed).
: "
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Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 659-68, (2002) (PubMed).
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- Target
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- Alternative Name
- Lamp-1 (LAMP1 Products)
- Synonyms
- CD107a antibody, LAMPA antibody, LGP120 antibody, AI196048 antibody, Lamp-1 antibody, LEP100 antibody, LAMP-1 antibody, LGP-A antibody, Lgpa antibody, Lysosome-associated membrane protein 1 antibody, cd107a antibody, lamp-1 antibody, lamp1 antibody, lampa antibody, lgp120 antibody, rexp76 antibody, lysosomal associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 L homeolog antibody, LAMP1 antibody, Lamp1 antibody, lamp1.L antibody
- Background
- Lysosomes are digestive compartments in mammalian cells that are responsible for the degradation of numerous substances including foreign materials. The lysosomal membrane is of interest due to its role in maintaining the acidic intralysosomal sac, its resistance to degradation, and its ability to fuse with other membranous organelles. Lamp-1 and lamp-2 (lysosomal-associated membrane proteins -1 and -2) were identified as lysosomal membrane proteins that act as carriers for poly-N-glycans, primarily N-acetyllactosamines. They consist of two heavily glycosylated amino terminal domains, a single trans-membrane domain, and a short cytoplasmic tail. A tyrosine located at the fourth residue from the end of the cytoplasmic tail, a large hydrophobic amino acid as the last residue, and a glycine residue amino terminal to the tyrosine residue targets these proteins from the TGN to the lysosome. The role of the Lamp molecules may be a carrier for poly-N-acetyllactosamines and/or to protect lysosomal membranes from the soluble hydrolases. This antibody is routinely tested by western blot analysis.
- Molecular Weight
- 110 kDa
- Pathways
- Autophagy
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