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RAD23B antibody (AA 73-193)

RAD23B Reactivity: Human, Dog WB, IF Host: Mouse Monoclonal 16-hHR23B unconjugated
Catalog No. ABIN968319
  • Target See all RAD23B Antibodies
    RAD23B (RAD23 Homolog B (RAD23B))
    Binding Specificity
    • 15
    • 13
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 73-193
    Reactivity
    • 88
    • 37
    • 36
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Dog
    Host
    • 69
    • 18
    • 1
    Mouse
    Clonality
    • 71
    • 17
    Monoclonal
    Conjugate
    • 48
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAD23B antibody is un-conjugated
    Application
    • 68
    • 29
    • 25
    • 15
    • 15
    • 14
    • 13
    • 10
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human hHR23B aa. 73-193
    Clone
    16-hHR23B
    Isotype
    IgG1
    Top Product
    Discover our top product RAD23B Primary Antibody
  • Comment

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Wakasugi, Sancar: "Assembly, subunit composition, and footprint of human DNA repair excision nuclease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 12, pp. 6669-74, (1998) (PubMed).

    Reardon, Mu, Sancar: "Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease." in: The Journal of biological chemistry, Vol. 271, Issue 32, pp. 19451-6, (1996) (PubMed).

    Sugasawa, Masutani, Uchida, Maekawa, van der Spek, Bootsma, Hoeijmakers, Hanaoka: "HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro." in: Molecular and cellular biology, Vol. 16, Issue 9, pp. 4852-61, (1996) (PubMed).

    Masutani, Sugasawa, Yanagisawa, Sonoyama, Ui, Enomoto, Takio, Tanaka, van der Spek, Bootsma: "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23." in: The EMBO journal, Vol. 13, Issue 8, pp. 1831-43, (1994) (PubMed).

  • Target
    RAD23B (RAD23 Homolog B (RAD23B))
    Alternative Name
    hHR23B (RAD23B Products)
    Synonyms
    HHR23B antibody, HR23B antibody, P58 antibody, 0610007D13Rik antibody, AV001138 antibody, mHR23B antibody, p58 antibody, MGC107846 antibody, zgc:65951 antibody, RAD23 homolog B, nucleotide excision repair protein antibody, UV excision repair protein RAD23 homolog B antibody, RAD23 homolog B, nucleotide excision repair protein S homeolog antibody, RAD23B antibody, Rad23b antibody, rd23b antibody, rad23b antibody, rad23b.S antibody
    Background
    Nucleotide excision repair (NER) is an essential element of DNA repair which eliminates unrelated DNA base lesions, including those induced by UV irradiation or chemicals. Although well defined in prokaryotes, eukaryotic NER is complex and involves at least two distinct subpathways. The transcription-coupled repair subpathway eliminates DNA lesions just prior to transcription. This is important for the removal of lesions for which the second pathway, global genome repair (i.e. covers the entire genome), is unable to repair. Individuals with defects in both pathways may suffer from xeroderma pigmentosum (XP), a condition with increased incidence of cancer in skin and internal organs. Mutations in seven genes result in human XP. However, one of these, XP-C, affects only the global genome repair pathway. The XP-C protein interacts with hHR23B, the human homolog of RAD23, an essential component of yeast NER. The XPC-hHR23B complex is required for excision of thymine dimers. In addition, hHR23B contains an N-terminal ubiquitin-like domain that allows for proteasome interaction. Thus, hHR23B may be an essential component of NER and mechanisms of DNA repair. This antibody is routinely tested by western blot analysis.
    Molecular Weight
    58 kDa
    Pathways
    DNA Damage Repair
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