Metabotropic Glutamate Receptor 1 antibody (AA 1042-1160)

Catalog No. ABIN968280

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Binding Specificity: AA 1042-1160

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Mouse (Murine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat mGluR1 aa. 1042-1160

Clone: 20-mGluR1

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-Metabotropic Glutamate Receptor 1 antibody (ABIN968280)

Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).

Mary, Gomeza, Prézeau, Bockaert, Pin: "A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 425-32, (1998) (PubMed).

Gomeza, Joly, Kuhn, Knöpfel, Bockaert, Pin: "The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins." in: The Journal of biological chemistry, Vol. 271, Issue 4, pp. 2199-205, (1996) (PubMed).

Tanabe, Masu, Ishii, Shigemoto, Nakanishi: "A family of metabotropic glutamate receptors." in: Neuron, Vol. 8, Issue 1, pp. 169-79, (1992) (PubMed).

Masu, Tanabe, Tsuchida, Shigemoto, Nakanishi: "Sequence and expression of a metabotropic glutamate receptor." in: Nature, Vol. 349, Issue 6312, pp. 760-5, (1991) (PubMed).

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: mGluR1 (GRM1 Products)

Synonyms: fj39d05 antibody, wu:fj39d05 antibody, si:ch211-51a19.1 antibody, Glura antibody, mGlutR antibody, GB18621 antibody, GPRC1A antibody, MGLU1 antibody, MGLUR1 antibody, SCAR13 antibody, 4930455H15Rik antibody, ENSMUSG00000075319 antibody, Gm10828 antibody, Gprc1a antibody, mGluR1 antibody, nmf373 antibody, rcw antibody, wobl antibody, glutamate metabotropic receptor 1 antibody, glutamate receptor, metabotropic 1a antibody, metabotropic glutamate receptor 1 antibody, glutamate receptor, metabotropic 1 antibody, GRM1 antibody, grm1a antibody, mGlutR1 antibody, Grm1 antibody

Background: Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca[2+] sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+ mobilization necessary for many signal transduction events.
Synonyms: Metabotropic Glutamate Receptor-1

Molecular Weight: 133 kDa