Striatin antibody (AA 450-600)

Catalog No. ABIN968207

Product Details anti-Striatin Antibody

Target: Striatin (STRN)

Binding Specificity: AA 450-600

Reactivity: Human, Mouse, Rat, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This Striatin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Mouse (Murine), Human, Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Striatin aa. 450-600

Clone: 6-Striatin

Isotype: IgG2b

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-Striatin antibody (ABIN968207)

Castets, Rakitina, Gaillard, Moqrich, Mattei, Monneron: "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19970-7, (2000) (PubMed).

Castets, Bartoli, Barnier, Baillat, Salin, Moqrich, Bourgeois, Denizot, Rougon, Calothy, Monneron: "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons." in: The Journal of cell biology, Vol. 134, Issue 4, pp. 1051-62, (1996) (PubMed).

Target Details for Striatin

Target: Striatin (STRN)

Alternative Name: Striatin (STRN Products)

Synonyms: SG2NA antibody, AU022939 antibody, D130055P19 antibody, Xstriatin antibody, strn antibody, striatin antibody, striatin, calmodulin binding protein antibody, striatin S homeolog antibody, STRN antibody, Strn antibody, strn.S antibody

Background: Signal transmission between neurons is regulated by the Ca2+-dependent release of neurotransmitters at the synapse. Striatin is a protein identified in the synaptosomal fraction of rat brain. Reports of sequence homology searches have shown that striatin belongs to a family of proteins with the repeated WD motif (the beta-transducin repeat or the WD-40 repeat) found in regulatory proteins. Striatin also binds calmodulin in a Ca2+-dependent manner. Immunolocalization and mRNA expression found striatin in the central nervous system, particularly enriched in neurons of the striatum and motor neurons. Furthermore, subcellular localization studies indicated that Striatin is tightly associated with the plasma membrane. Thus, striatin may play an important role in the Ca2+-dependent events occurring at the synapse.

Molecular Weight: 110 kDa

Pathways: Nuclear Hormone Receptor Binding, Cell-Cell Junction Organization