RAB11A antibody (AA 86-207)

Catalog No. ABIN968091

Product Details anti-RAB11A Antibody

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Binding Specificity: AA 86-207

Reactivity: Human, Mouse, Rat, Dog, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAB11A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Dog (Canine), Chicken, Mouse (Murine), Rat (Rattus)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Rab11 aa. 86-207

Clone: 47-Rab11

Isotype: IgG2a

Application Details

Comment:

Related Products: ABIN968619, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-RAB11A antibody (ABIN968091)

Steiner, Sarria, Glauser, Magnin, Catsicas, Hirling: "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD." in: The Journal of cell biology, Vol. 157, Issue 7, pp. 1197-209, (2002) (PubMed).

Choudhury, Dominguez, Puri, Sharma, Narita, Wheatley, Marks, Pagano: "Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells." in: The Journal of clinical investigation, Vol. 109, Issue 12, pp. 1541-50, (2002) (PubMed).

Woods, Roberts, Choudhary, Barry, Mazaki, Sabe, Morley, Critchley, Norman: "Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 6428-37, (2002) (PubMed).

Lai, Stubbs, Artzt: "Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein." in: Genomics, Vol. 22, Issue 3, pp. 610-6, (1995) (PubMed).

Sakurada, Uchida, Yamaguchi, Aisaka, Ito, Ohmori, Takeyama, Ueda, Hori, Ohyanagi: "Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver." in: Biochemical and biophysical research communications, Vol. 177, Issue 3, pp. 1224-32, (1991) (PubMed).

Target Details for RAB11A

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Alternative Name: Rab11 (RAB11A Products)

Synonyms: rab11 antibody, RAB11A antibody, wu:fi15h09 antibody, zgc:103679 antibody, yl8 antibody, Rab11a antibody, rab11A antibody, DDBDRAFT_0190819 antibody, DDBDRAFT_0191190 antibody, DDB_0190819 antibody, DDB_0191190 antibody, YL8 antibody, RAB11 antibody, RAB11A, member RAS oncogene family S homeolog antibody, RAB11A, member RAS oncogene family antibody, RAB11a, member RAS oncogene family antibody, Rab11 GTPase antibody, rab11A protein antibody, Rab11a, GTPase antibody, Rab GTPase antibody, rab11A, RAB family GTPase antibody, rab11a.S antibody, RAB11A antibody, rab11a antibody, Rab11a antibody, rab11A antibody

Background: The Rab proteins are small GTP-binding molecules that are localized to specific intracellular vesicles and organelles. It has been proposed that Rab proteins cycle between GTP- and GDP-bound forms and that this is related to their function as regulators of vesicular traffic. The Rab11 gene encodes a 24 kDa protein of 214 amino acids that has been detected in liver, brain, testis, spleen, and heart. Rab11 protein was isolated from the golgi-microsomal fraction of rat liver and has been detected in the Trans-golgi Network, secretory vesicles, and the pericentriolar recycling endosomes. The distribution of Rab11 indicates that this small protein is involved in regulating traffic at the Golgi complex.

Molecular Weight: 24 kDa

Pathways: Regulation of Cell Size, Thromboxane A2 Receptor Signaling, Regulation of long-term Neuronal Synaptic Plasticity