YES1 antibody (AA 10-193)

Catalog No. ABIN967926

Product Details anti-YES1 Antibody

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Binding Specificity: AA 10-193

Reactivity: Human, Mouse, Rat, Dog, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This YES1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Yes aa. 10-193

Clone: 1-Yes

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968533, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-YES1 antibody (ABIN967926)

Chen, Lu, Goodenough, Jeansonne: "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells." in: Molecular biology of the cell, Vol. 13, Issue 4, pp. 1227-37, (2002) (PubMed).

Lee, Bonnah, Higashi, Atkinson, Milgram, So: "CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae." in: The Journal of cell biology, Vol. 156, Issue 6, pp. 951-7, (2002) (PubMed).

Encinas, Tansey, Tsui-Pierchala, Comella, Milbrandt, Johnson: "c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 5, pp. 1464-72, (2001) (PubMed).

Arizmendi, Family, Salas-Brito: "Quenched disorder effects on deterministic inertia ratchets." in: Physical review. E, Statistical, nonlinear, and soft matter physics, Vol. 63, Issue 6 Pt 1, pp. 61104, (2001) (PubMed).

Park, Cartwright: "Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells." in: Molecular and cellular biology, Vol. 15, Issue 5, pp. 2374-82, (1995) (PubMed).

Sukegawa, Semba, Yamanashi, Nishizawa, Miyajima, Yamamoto, Toyoshima: "Characterization of cDNA clones for the human c-yes gene." in: Molecular and cellular biology, Vol. 7, Issue 1, pp. 41-7, (1987) (PubMed).

Target Details for YES1

Target: YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))

Alternative Name: Yes (YES1 Products)

Synonyms: HsT441 antibody, P61-YES antibody, Yes antibody, c-yes antibody, yes antibody, p61-Yes antibody, hst441 antibody, p61-yes antibody, YES antibody, c-Yes antibody, p60c-yes antibody, YES proto-oncogene 1, Src family tyrosine kinase antibody, YES proto-oncogene 1, Src family tyrosine kinase L homeolog antibody, YES1 antibody, yes1.L antibody, yes1 antibody, Yes1 antibody

Background: Yes is a member of the Src family of tyrosine kinases. The cellular gene was initially identified as a homologue of v-yes, the oncogene of avian sarcoma virus Y73. At least nine different Src family members have been identified. yes, fyn, and Src are widely expressed in a variety of cell types, while the remaining members are primarily expressed in hematopoietic cells. Members of this family have several common features: they have unique N-terminal domains, they attach to cellular membranes through a myristylated N-terminus and they have homologus SH2, SH3, and catalytic domains. The common expression patterns of Yes, fyn, and Src suggest some overlapping functions. All three of these kinases can physically associate with a number of cell-surface molecules which appear to increase their catalytic activity.

Molecular Weight: 62 kDa

Pathways: CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling